(estradiol +/- norethisterone acetate)
What is Elleste™?
Elleste™ is a hormone replacement therapy
(HRT) which is used to provide relief from the
symptoms of menopause.1-7
Elleste is a hormone replacement therapy (HRT)
indicated in estrogen deficiency symptoms
in post- and peri-menopausal women. During the menopausal transition, the levels of estrogen in a woman’s body start to decline. These hormonal variations can cause vasomotor symptoms like hot flushes and night sweats and also other psychological symptoms.8 Vasomotor symptoms are quite common during perimenopause and usually respond well to estrogen therapy. However, the addition of a progestogen is required in women who have an intact uterus to prevent endometrial hyperplasia and cancer.3-5
Benefits of combination therapy of estradiol and norethisterone acetate
The addition of a progestogen cyclically for at least 12 days per month/28 day cycle or continuous combined estrogen-progestogen therapy in non-hysterectomised women prevents the excessive risk of endometrial hyperplasia and carcinoma associated with estrogen-only HRT.3-5
In a small study to assess the role of low-dose HRT on the quality of life in 50 early postmenopausal women, it concluded that low-dose HRT of 17β-estradiol (1 mg/day) and norethisterone acetate (0.5 mg/day) can positively improve vasomotor symptoms and general aspects of physical and psychological well-being of symptomatic postmenopausal women.9
The Elleste™ range
|Regime||Estradiol dose||Pack||Price (£)10|
|Elleste Duet™||Continuous Sequential HRT||1mg or 2mg||3 X 28||9.20|
|Elleste Duet™ Conti||Continuous Combined HRT||2mg||3 X 28||17.02|
|Elleste Solo™||Continuous Estrogen only||1mg or 2mg||3 X 28||5.06|
|Elleste Solo™ MX||Continuous Estrogen only||40μg||8 x patches||5.19|
|Elleste Solo™ MX||Continuous Estrogen only||80μg||8 x patches||5.99|
These products are additionally licensed for the prevention of osteoporosis in post-menopausal women at high risk of the future fractures who are intolerant of, or contraindicated for, other medical products.
What is the composition of Elleste™?
Elleste™ is available orally in 3 different preparations. Elleste Solo™ contains estradiol only and is suitable for hysterectomised women.1,2 Whereas Elleste Duet™ is a sequential combined therapy containing estradiol and norethisterone acetate which is available as estradiol 1mg and 2mg tablets for perimenopausal women.3,4 Elleste Duet™ Conti which is a continuous combined therapy at 2mg for postmenopausal women.5 Elleste™ is also available in a transdermal preparation, containing estradiol only in the form of Elleste Solo™ MX 40mcg and 80mcg which is suitable for hysterectomised women.6,7
Indications of Elleste™
Elleste™ is indicated for post- and peri-menopausal women1-7 with estrogen deficiency symptoms, such as hot flushes and night sweats which are a result of declining estrogen levels. Additionally, menopausal women are at an increased risk of osteoporosis; Elleste Solo™ MX 80mcg, Elleste Solo™ 2mg, Elleste Duet™ 2mg and Elleste Duet™ 2mg are licensed for the prevention of osteoporosis in postmenopausal women at high risk of future fractures who are intolerant of, or contraindicated for, other medicinal products approved for the prevention of osteoporosis.2,4,5,7
Adverse effects and precautions for use of Elleste™
The side effects of Elleste™ can range from headaches, nausea, bloating and diarrhoea to breast tenderness and irregular vaginal bleeding. Side effects may vary by product. For a full list of adverse effects, please consult the product SmPC.1-7
Contraindications to prescribing Elleste™ include: known, past or suspected breast cancer; known or suspected estrogen-dependent malignant tumours (e.g. endometrial cancer); undiagnosed genital bleeding; untreated endometrial hyperplasia; previous or current venous thromboembolism (deep venous thrombosis, pulmonary embolism); known thrombophilic disorders (e.g. protein C, protein S, or antithrombin deficiency); active or recent arterial thromboembolic disease (e.g. angina, myocardial infarction); acute liver disease, or a history of liver disease as long as liver function tests have failed to return to normal; hypersensitivity to the active substances or to any of the excipients listed; porphyria.
The contraindications may vary by product, please consult each products' individual SmPC for the list of contraindications.1-7